phe-arg B-naphthylamide dihydrochloride
PAβN (dihydrochloride)
CAS: 100929-99-5
Molecular Formula: C25H32Cl2N6O2
phe-arg B-naphthylamide dihydrochloride - Names and Identifiers
phe-arg B-naphthylamide dihydrochloride - Physico-chemical Properties
| Molecular Formula | C25H32Cl2N6O2 |
| Molar Mass | 519.47 |
| Melting Point | >250o C |
| Solubility | Methanol (Slightly), Water (Slightly) |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | -20°C |
| In vitro study | PAβN increases the susceptibilities of the three pump-overexpressing mutants of P. aeruginosa to levofloxacin 64-fold. PAβN also potentiates the activity of levofloxacin against strain PAM2391 containing plasmid pAGH97 with the mexXY genes and against wild-type strain PAM1020. PAβN has an effect on susceptibilities to other antibiotics that are substrates of efflux pumps. PAβN increases levels of accumulation of efflux pump substrates inside the cell. It enhances the activity of levofloxacin against clinical isolates of P. aeruginosa . PAβN reduces the MICs in nine ciprofloxacin-resistant isolates, and in four of these, PAβN increases the susceptibility by twofold. Moreover, PAβN restores ciprofloxacin susceptibility in five of the ciprofloxacin-resistant isolates. In addition, clear effects of NMP on the ciprofloxacin MICs are seen for 20 of these ciprofloxacin-resistant isolates. PAβN permeabilizes bacterial membranes in a concentration-dependent manner at levels below those typically used in combination studies, and this additional mode of action should be considered when using PAβN as a control for efflux studies. |
phe-arg B-naphthylamide dihydrochloride - Risk and Safety
| WGK Germany | 3 |
phe-arg B-naphthylamide dihydrochloride - Reference Information
| biological activity | paβn dihydrozolide (MC-207110 dihydrozolide) is an inhibitor of the efflux pump. |
Last Update：2024-04-09 21:54:55
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